A Cell-Based Method to Detect Agonist and Antagonist Activities of Endocrine-Disrupting Chemicals on GPER - CIRI - Inflammasome NLRP3 et réponse immunitaire au sepsis
Article Dans Une Revue Frontiers in Endocrinology Année : 2020

A Cell-Based Method to Detect Agonist and Antagonist Activities of Endocrine-Disrupting Chemicals on GPER

Résumé

Endocrine-disrupting chemicals (EDCs) are exogenous compounds that impact endogenous hormonal systems, resulting in adverse health effects. These chemicals can exert their actions by interfering with several pathways. Simple biological systems to determine whether EDCs act positively or negatively on a given receptor are often lacking. Here we describe a low-to-middle throughput method to screen the agonist/antagonist potential of EDCs specifically on the GPER membrane estrogen receptor. Application of this assay to 23 candidate EDCs from different chemical families reveals the existence of six agonists and six antagonists.
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hal-03388663 , version 1 (20-10-2021)

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Séverine Périan, Catherine Cerutti, Christelle Forcet, Violaine Tribollet, Jean-Marc Vanacker. A Cell-Based Method to Detect Agonist and Antagonist Activities of Endocrine-Disrupting Chemicals on GPER. Frontiers in Endocrinology, 2020, 11, ⟨10.3389/fendo.2020.00547⟩. ⟨hal-03388663⟩
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