The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF‐I, IGF‐II, IGFBP‐1, IGFBP‐2 and IGFBP‐3 in a pooled analysis of 16,024 men from 22 studies
Eleanor Watts
(1)
,
Aurora Perez‐cornago
(1)
,
Paul Appleby
(1)
,
Demetrius Albanes
(2)
,
Eva Ardanaz
(3)
,
Amanda Black
(2)
,
H. Bas Bueno‐de‐mesquita
(4)
,
June Chan
(5)
,
Chu Chen
(6)
,
S.A. Paul Chubb
(7)
,
Michael Cook
(2)
,
Mélanie Deschasaux
(8)
,
Jenny Donovan
(9)
,
Dallas R English
(10)
,
Leon Flicker
(7)
,
Neal Freedman
(2)
,
Pilar Galan
(8)
,
Graham G Giles
(10)
,
Edward Giovannucci
(11, 12)
,
Marc Gunter
(13)
,
Laurel Habel
(14)
,
Christel Häggström
(15)
,
Christopher Haiman
(16)
,
Freddie C. Hamdy
(17)
,
Serge Hercberg
(8)
,
Jeff Holly
(9)
,
Jiaqi Huang
(2)
,
Wen‐yi Huang
(2)
,
Mattias Johansson
(13)
,
Rudolf Kaaks
(18)
,
Tatsuhiko Kubo
(19)
,
J. Athene Lane
(9)
,
Tracy Layne
(20)
,
Loïc Le Marchand
(21)
,
Richard Martin
(9)
,
E. Jeffrey Metter
(22)
,
Kazuya Mikami
(23)
,
Roger L Milne
(10)
,
Howard Morris
(24)
,
Lorelei Mucci
(11)
,
David Neal
(17)
,
Marian Neuhouser
(6)
,
Steven Oliver
(25)
,
Kim Overvad
(26)
,
Kotaro Ozasa
(27)
,
Valeria Pala
(28)
,
Claire Pernar
(11)
,
Michael Pollak
(29)
,
Mari‐anne Rowlands
(9)
,
Catherine Schaefer
(14)
,
Jeannette Schenk
(6)
,
Pär Stattin
(30)
,
Akiko Tamakoshi
(31)
,
Elin Thysell
(15)
,
Mathilde Touvier
(8)
,
Antonia Trichopoulou
(32)
,
Konstantinos Tsilidis
(33, 34)
,
Stephen K. van den Eeden
(14)
,
Stephanie Weinstein
(2)
,
Lynne Wilkens
(21)
,
Bu Yeap
(7)
,
Timothy Key
(35)
,
Naomi E. Allen
(1)
,
Ruth Travis
(35)
1
Nuffield Department of Population Health [Oxford]
2 NCI-NIH - National Cancer Institute [Bethesda]
3 Public Health Institute of Navarra
4 RIVM - National Institute for Public Health and the Environment [Bilthoven]
5 UC San Francisco - University of California [San Francisco]
6 FHCRC - Fred Hutchinson Cancer Research Center [Seattle]
7 UWA - The University of Western Australia
8 CRESS - U1153 - Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
9 University of Bristol [Bristol]
10 Melbourne School of Population and Global Health [Melbourne]
11 Harvard T.H. Chan School of Public Health
12 HMS - Harvard Medical School [Boston]
13 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
14 Kaiser Permanente
15 Umeå University
16 Keck School of Medicine [Los Angeles]
17 Nuffield - Nuffield
18 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
19 UEOH - University of Occupational and Environmental Health [Kitakyushu]
20 MSSM - Icahn School of Medicine at Mount Sinai [New York]
21 UH - University of Hawai'i [Honolulu]
22 UTHSC - The University of Tennessee Health Science Center [Memphis]
23 Japanese Red Cross Kyoto Daiichi Hospital
24 SA Pathology [Adelaide, SA, Australia]
25 University of York [York, UK]
26 Aarhus University [Aarhus]
27 RERF - Radiation Effects Research Foundation [Hiroshima City, Japan]
28 Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan]
29 McGill University = Université McGill [Montréal, Canada]
30 Uppsala Universitet [Uppsala]
31 Hokkaido University [Sapporo, Japan]
32 Hellenic Health Foundation
33 Imperial College London
34 University of Ioannina
35 University of Oxford
2 NCI-NIH - National Cancer Institute [Bethesda]
3 Public Health Institute of Navarra
4 RIVM - National Institute for Public Health and the Environment [Bilthoven]
5 UC San Francisco - University of California [San Francisco]
6 FHCRC - Fred Hutchinson Cancer Research Center [Seattle]
7 UWA - The University of Western Australia
8 CRESS - U1153 - Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
9 University of Bristol [Bristol]
10 Melbourne School of Population and Global Health [Melbourne]
11 Harvard T.H. Chan School of Public Health
12 HMS - Harvard Medical School [Boston]
13 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
14 Kaiser Permanente
15 Umeå University
16 Keck School of Medicine [Los Angeles]
17 Nuffield - Nuffield
18 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
19 UEOH - University of Occupational and Environmental Health [Kitakyushu]
20 MSSM - Icahn School of Medicine at Mount Sinai [New York]
21 UH - University of Hawai'i [Honolulu]
22 UTHSC - The University of Tennessee Health Science Center [Memphis]
23 Japanese Red Cross Kyoto Daiichi Hospital
24 SA Pathology [Adelaide, SA, Australia]
25 University of York [York, UK]
26 Aarhus University [Aarhus]
27 RERF - Radiation Effects Research Foundation [Hiroshima City, Japan]
28 Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan]
29 McGill University = Université McGill [Montréal, Canada]
30 Uppsala Universitet [Uppsala]
31 Hokkaido University [Sapporo, Japan]
32 Hellenic Health Foundation
33 Imperial College London
34 University of Ioannina
35 University of Oxford
Mélanie Deschasaux
- Fonction : Auteur
- PersonId : 183648
- IdHAL : melanie-deschasaux
- ORCID : 0000-0002-3359-420X
- IdRef : 236007823
Pilar Galan
- Fonction : Auteur
- PersonId : 756893
- ORCID : 0000-0003-1706-3107
Serge Hercberg
- Fonction : Auteur
- PersonId : 1136672
- ORCID : 0000-0002-3168-1350
- IdRef : 02858709X
Mattias Johansson
- Fonction : Auteur
- PersonId : 767866
- ORCID : 0000-0002-3116-5081
- IdRef : 195811100
Valeria Pala
- Fonction : Auteur
- PersonId : 764917
- ORCID : 0000-0001-5438-970X
Mathilde Touvier
- Fonction : Auteur
- PersonId : 1136541
Résumé
Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...
