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Modifications post-traductionnelles des lipoprotéines de haute densité (HDL) et risque cardio-vasculaire dans l’insuffisance rénale chronique

Abstract : Cardiovascular complications remain the main problem in chronic kidney disease (CKD) but all the reasons of this risk are not fully understood. there is an addition of traditional risk factors and uremia-related ones. Among the latter, the generation of post-translational modifications of HDL could play a role. In this work, we highlighted an excess of carbonylation by 4-HNE onto the protein part of HDL in CKD in a rabbit model of CKD and in hemodialysis and peritoneal dialysis patients. This carbonylation by 4-HNE is responsible for ablunted anti-aggregant properties of HDL mediated by a CD36-dependant pathway. We also showed that the proteome of HDL from non diabetic hemodialysis patients is deeply modified and that there were several post-translational modifications onto the protein cargo of these HDL. The generation of carboxylate-methyl-lysine from non-enzymatic glycation processes was the main modification in our patients. The origin of such glycation could be from a favorable chemical environment but a potential load from hemodialysis fluids should be addressed
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Submitted on : Tuesday, May 19, 2020 - 10:19:09 AM
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  • HAL Id : tel-02611733, version 2

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Nans Florens. Modifications post-traductionnelles des lipoprotéines de haute densité (HDL) et risque cardio-vasculaire dans l’insuffisance rénale chronique. Santé. Université de Lyon, 2020. Français. ⟨NNT : 2020LYSE1034⟩. ⟨tel-02611733v2⟩

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