The growing of ageing population worldwide and the need to focus research efforts on a specific target group motivate our research to focus on frail ageing people with chronic disease and physical/cognitive deficiencies. The primary goal is to enable the frail and dependant persons, through reliable assistive technologies, to maximize their physical and mental functions, and to continue to engage them in social networks, so that he can continue to lead an independent and purposeful life. Our target is to analyze the users’ habits at home through an extensive survey performed in France recently, and to design a suitable assistive system, which is mainly composed of devices available in the market. This research activity led to the deployment of a simplified hardware infrastructure (gateway, sensors, actuators) in the home of end-users with a limited number of wireless sensors, and to the outsourcing of all the software for data analysis in a framework running on a distant server. The research focuses on the quality of life of ageing people having cognitive and functional limitations, and on recent achievements realised in France and Singapore through several European and national projects, and through Quality of Life Chair (QoL) directed by Mounir Mokhtari and supported by two major health insurance companies in France, namely la Mutuelle Generale and REUNICA.