I. Yeh and R. Altman, Drug Targets for Plasmodium falciparum: A Post-Genomic Review/Survey, Mini-Reviews in Medicinal Chemistry, vol.6, issue.2, pp.177-202, 2006.
DOI : 10.2174/138955706775475957

B. Greenwood, D. Fidock, D. Kyle, S. Kappe, P. Alonso et al., Malaria: progress, perils, and prospects for eradication, Journal of Clinical Investigation, vol.118, issue.4, pp.1266-1276, 2008.
DOI : 10.1172/JCI33996

M. Gardner, N. Hall, E. Fung, O. White, M. Berriman et al., Genome sequence of the human malaria parasite Plasmodium falciparum, Nature, vol.241, issue.6906, pp.419498-511, 2002.
DOI : 10.1038/nature01099

S. Adl, B. Leander, A. Simpson, J. Archibald, O. Anderson et al., Diversity, Nomenclature, and Taxonomy of Protists, Systematic Biology, vol.56, issue.4, pp.684-689, 2007.
DOI : 10.1080/10635150701494127

S. Baldauf, The Deep Roots of Eukaryotes, Science, vol.300, issue.5626, pp.1703-1706, 2003.
DOI : 10.1126/science.1085544

E. Pizzi and C. Frontali, Low-Complexity Regions in Plasmodium falciparum Proteins, Genome Research, vol.11, issue.2, pp.218-229, 2001.
DOI : 10.1101/gr.GR-1522R

S. Altschul, W. Gish, W. Miller, E. Myers, and D. Lipman, Basic local alignment search tool, Journal of Molecular Biology, vol.215, issue.3, pp.403-410, 1990.
DOI : 10.1016/S0022-2836(05)80360-2

O. Bastien, S. Roy, and E. Marechal, Construction of non-symmetric substitution matrices derived from proteomes with biased amino acid distributions, Comptes Rendus Biologies, vol.328, issue.5, pp.445-453, 2005.
DOI : 10.1016/j.crvi.2005.02.002

E. Sonnhammer, S. Eddy, E. Birney, A. Bateman, and R. Durbin, Pfam: multiple sequence alignments and HMM-profiles of protein domains, Nucleic Acids Research, vol.26, issue.1, pp.320-322, 1998.
DOI : 10.1093/nar/26.1.320

M. Punta and Y. Ofran, The Rough Guide to In Silico Function Prediction, or How To Use Sequence and Structure Information To Predict Protein Function, PLoS Computational Biology, vol.11, issue.10, 2008.
DOI : 10.1371/journal.pcbi.1000160.s001

M. Eisen, P. Spellman, P. Brown, and D. Botstein, Cluster analysis and display of genome-wide expression patterns, Proceedings of the National Academy of Sciences, vol.95, issue.25, pp.9514863-14868, 1998.
DOI : 10.1073/pnas.95.25.14863

D. Lockhart and E. Winzeler, Genomics, gene expression and DNA arrays, Nature, vol.405, issue.6788, pp.827-836, 2000.
DOI : 10.1038/35015701

L. Roch, K. Zhou, Y. Blair, P. Grainger, M. Moch et al., Discovery of gene function by expression profiling of the malaria parasite life cycle, Science, issue.5639, pp.3011503-1508, 2003.

Y. Zhou, V. Ramachandran, K. Kumar, S. Westenberger, P. Refour et al., Evidence-Based Annotation of the Malaria Parasite's Genome Using Comparative Expression Profiling, PLoS ONE, vol.100, issue.2, p.1570, 2008.
DOI : 10.1371/journal.pone.0001570.s004

L. Bréhélin, J. Dufayard, and O. Gascuel, PlasmoDraft: a database of Plasmodium falciparum gene function predictions based on postgenomic data, BMC Bioinformatics, vol.9, issue.1, p.440, 2008.
DOI : 10.1186/1471-2105-9-440

V. Van-noort, B. Snel, and M. Huynen, Predicting gene function by conserved co-expression, Trends in Genetics, vol.19, issue.5, pp.238-242, 2003.
DOI : 10.1016/S0168-9525(03)00056-8

J. Stuart, E. Segal, D. Koller, and S. Kim, A Gene-Coexpression Network for Global Discovery of Conserved Genetic Modules, Science, vol.302, issue.5643, pp.249-255, 2003.
DOI : 10.1126/science.1087447

B. Dutilh, M. Huynen, and B. Snel, A global definition of expression context is conserved between orthologs, but does not correlate with sequence conservation, BMC Genomics, vol.7, 2006.

Z. Bozdech, M. Llinas, B. Pulliam, E. Wong, J. Zhu et al., The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum, PLoS Biology, vol.280, issue.1, p.5, 2003.
DOI : 10.1371/journal.pbio.0000005.st007

A. Gasch, P. Spellman, C. Kao, O. Eisen, M. Storz et al., Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes, Molecular Biology of the Cell, vol.11, issue.12, pp.114241-4257, 2000.
DOI : 10.1091/mbc.11.12.4241

P. Spellman, G. Sherlock, M. Zhang, V. Iyer, K. Anders et al., Comprehensive identification of cell cycleregulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization, Mol Biol Cell, issue.912, pp.3273-3297, 1998.

F. Pilot, P. J. Lemmers, C. Chauvin, J. Lecuit, and T. , Developmental control of nuclear morphogenesis and anchoring by charleston, identified in a functional genomic screen of Drosophila cellularisation, Development, vol.133, issue.4, pp.711-723, 2006.
DOI : 10.1242/dev.02251

URL : https://hal.archives-ouvertes.fr/hal-00088580

S. Lloyd, Least squares quantization in PCM, IEEE Transactions on Information Theory, vol.28, issue.2, pp.129-137, 1982.
DOI : 10.1109/TIT.1982.1056489

R. Herwig, A. Poustka, C. Muller, C. Bull, H. Lehrach et al., Large-Scale Clustering of cDNA-Fingerprinting Data, Genome Research, vol.9, issue.11, pp.1093-105, 1999.
DOI : 10.1101/gr.9.11.1093

L. Rabiner, A Tutorial on Hidden Markov Models and Selected Applications in Speech Recognition, Proceedings of the IEEE 1989, pp.257-285

R. Durbin, S. Eddy, A. Krogh, and G. Mitchison, Biological sequence analysis probabilistic models of proteins and nucleic acids, 1998.

G. Mclachlan and D. Peel, Finite mixture models, 2000.
DOI : 10.1002/0471721182

J. Barale, G. Attal-bonnefoy, K. Brahimi, P. Silva, and G. Langsley, Plasmodium falciparum asparagine and aspartate rich protein 2 is an evolutionary conserved protein whose repeats identify a new family of parasite antigens1Note: Nucleotide sequence data reported in this paper are available in the EMBL, GenBankTM and DDJB data bases under the accession numbers Y08924 and Y08925.1, Molecular and Biochemical Parasitology, vol.87, issue.2, pp.169-181, 1997.
DOI : 10.1016/S0166-6851(97)00065-0

T. Mccutchan, R. Van-spaendonk, C. Janse, J. Fang, and A. Waters, Malaria Parasites: Genomes and Molecular, Regulation of rRNA transcription and processing during the Plasmodium life cycle Biology, 2004.

P. Smits, J. Smeitink, L. Heuvel-van-den, M. Huynen, and T. Ettema, Reconstructing the evolution of the mitochondrial ribosomal proteome, Nucleic Acids Research, vol.35, issue.14, pp.4686-4703, 2007.
DOI : 10.1093/nar/gkm441

P. Mishra, A. Kumar, and A. Sharma, Analysis of small nucleolar RNAs reveals unique genetic features in malaria parasites, BMC Genomics, vol.10, issue.1, p.68, 2009.
DOI : 10.1186/1471-2164-10-68

E. Bottger, Antimicrobial agents targeting the ribosome: the issue of selectivity and toxicity ??? lessons to be learned, Cellular and Molecular Life Sciences, vol.64, issue.7-8, pp.791-795, 2007.
DOI : 10.1007/s00018-007-6431-5

B. Clough, M. Strath, P. Preiser, P. Denny, and I. Wilson, Thiostrepton binds to malarial plastid rRNA, FEBS Letters, vol.95, issue.1-2, pp.123-125, 1997.
DOI : 10.1016/S0014-5793(97)00241-X

M. Rogers, Y. Bukhman, T. Mccutchan, and D. Draper, Interaction of thiostrepton with an RNA fragment derived from the plastid-encoded ribosomal RNA of the malaria parasite, RNA, vol.3, issue.8, pp.815-820, 1997.

M. Camps, G. Arrizabalaga, and J. Boothroyd, An rRNA mutation identifies the apicoplast as the target for clindamycin in Toxoplasma gondii, Molecular Microbiology, vol.35, issue.5, pp.1309-1318, 2002.
DOI : 10.1046/j.1365-2958.2002.02825.x

R. Kiatfuengfoo, T. Suthiphongchai, P. Prapunwattana, and Y. Yuthavong, Mitochondria as the site of action of tetracycline on Plasmodium falciparum, Molecular and Biochemical Parasitology, vol.34, issue.2, pp.109-115, 1989.
DOI : 10.1016/0166-6851(89)90002-9

A. Yassin and A. Mankin, Potential New Antibiotic Sites in the Ribosome Revealed by Deleterious Mutations in RNA of the Large Ribosomal Subunit, Journal of Biological Chemistry, vol.282, issue.33, pp.24329-24342, 2007.
DOI : 10.1074/jbc.M703106200

A. Sidhu, Q. Sun, L. Nkrumah, M. Dunne, J. Sacchettini et al., In Vitro Efficacy, Resistance Selection, and Structural Modeling Studies Implicate the Malarial Parasite Apicoplast as the Target of Azithromycin, Journal of Biological Chemistry, vol.282, issue.4, pp.2494-2504, 2007.
DOI : 10.1074/jbc.M608615200

C. Doerig and D. Chakrabarti, Malaria Parasites: Genomes and Molecular Biology, Cell cycle control in Plasmodium falciparum: a genomic perspective Caister Academic PressWaters AP, 2004.

I. Tienda-luna, Y. Yin, M. Carrion, Y. Huang, H. Cai et al., Inferring the skeleton cell cycle regulatory network of malaria parasite using comparative genomic and variational Bayesian approaches, Genetica, vol.14, issue.Suppl 1, pp.131-142, 2008.
DOI : 10.1007/s10709-007-9155-4

P. Ward, L. Equinet, J. Packer, and C. Doerig, Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote, BMC Genomics, vol.5, issue.1, p.79, 2004.
DOI : 10.1186/1471-2164-5-79

URL : https://hal.archives-ouvertes.fr/inserm-00103327

B. Kappes and P. Rohrbach, Microtubule inhibitors as a potential treatment for malaria, Future Microbiology, vol.2, issue.4, pp.409-423, 2007.
DOI : 10.2217/17460913.2.4.409

C. Doerig and L. Meijer, Antimalarial drug discovery: targeting protein kinases, Expert Opinion on Therapeutic Targets, vol.419, issue.3, pp.279-290, 2007.
DOI : 10.1111/j.1432-1033.1997.t01-2-00527.x

URL : https://hal.archives-ouvertes.fr/hal-00169407

L. Birkholtz, A. Van-brummelen, K. Clark, J. Niemand, E. Marechal et al., Exploring functional genomics for drug target and therapeutics discovery in Plasmodia, Acta Tropica, vol.105, issue.2, pp.113-123, 2008.
DOI : 10.1016/j.actatropica.2007.10.013

URL : https://hal.archives-ouvertes.fr/hal-00250161

J. Young, Q. Fivelman, P. Blair, . De, P. Vega et al., The Plasmodium falciparum sexual development transcriptome: A microarray analysis using ontology-based pattern identification, Molecular and Biochemical Parasitology, vol.143, issue.1, pp.67-79, 2005.
DOI : 10.1016/j.molbiopara.2005.05.007