Presentation of the main approaches to build phylogenetic trees from sequence data. The focus will be on : (1) probabilistic models of sequence evolution (JC, K2P, HKY, GTR, JTT, WAG and LG) ; (2) modeling of rates accross sites using gama distributions ; (3) likelihood calculations; (4) tree inference approaches ; (5) bootstrap and other branch supports. I'll both explain the theory and train the students with practicals using standard programs and web servers (PHYLIP, PhyML, Phylogeny.fr).