In subjects with complete Spinal Cord Injury (SCI) above C7, the four limbs are paralyzed (quadriplegia). Recovery of grasping movements is then reported as a priority. Indeed, most activities of daily living are achieved through upper limbs. Thus, restoration of hand and forearm active mobility could significantly increase independence and quality of life of these people and decrease their need of human aid. Although most of the subjects plebiscite pharmacological or biological solutions, only orthotics and Functional Electrical Stimulation (FES) allow, so far, to restore hand movements but they are rarely used. Limited ergonomics and comfort of piloting modes could partly explain the low usage of these systems. In this context, our aim is to explore possible solutions for subjects to interact with such devices. In this article, we propose to evaluate the capacity of active upper limb muscles contraction to be used to intuitively control FES in tetraplegic subjects. In this study, we assessed the ability to gradually contract different muscles: trapezius, deltoid, platysma and biceps. Three subjects with C6 to C7 neurological levels of lesion were included. We show that over the active upper limb muscles tested, contraction of the trapezius muscle was considered by the subjects as the most comfortable and could be employed as an intuitive mode of control of functional assistive devices.