On-chip sine-wave signal generation is widely covered by literature for Built-In-Self Test (BIST) or biosensor applications. The objective is to generate pure and robust sine-wave signal with minimal hardware resources. An attractive solution consists in combining several digital signals to built this analog sine-wave. The objective of this paper is to give an analytical study of various potential solutions based on digital-based approaches. Thanks to this study, we prove that technique consisting in setting the phase shifts and various amplitude values of the square-wave signals is the most efficient approach. Moreover, this study allows the selection of the best solution in terms of parameters of the square-wave signals to cancel low-order harmonics of the generated signal.