G Protein-Coupled Receptors: Dominant Players in Cell-Cell Communication - LIRMM - Laboratoire d’Informatique, de Robotique et de Microélectronique de Montpellier Access content directly
Journal Articles International Review of Cytology Year : 2002

G Protein-Coupled Receptors: Dominant Players in Cell-Cell Communication


The G protein-coupled receptors (GPCRs) are the most numerous and the most diverse type of receptors (1–5% of the complete invertebrate and vertebrate genomes). They transduce messages as different as odorants, nucleotides, nucleosides, peptides, lipids, and proteins. There are at least eight families of GPCRs that show no sequence similarities and that use different domains to bind ligands and activate a similar set of G proteins. Homo- and heterodimerization of GPCRs seem to be the rule, and in some cases an absolute requirement, for activation. There are about 100 orphan GPCRs in the human genome which will be used to find new message molecules. Mutations of GPCRs are responsible for a wide range of genetic diseases. The importance of GPCRs in physiological processes is illustrated by the fact that they are the target of the majority of therapeutical drugs and drugs of abuse.
Fichier principal
Vignette du fichier
2002 IRC Bockaert (1).pdf (2.28 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

lirmm-00268610 , version 1 (05-03-2020)



Joël Bockaert, Sylvie Claeysen, Carine Becamel, Sylvie Pinloche, Aline Dumuis. G Protein-Coupled Receptors: Dominant Players in Cell-Cell Communication. International Review of Cytology, 2002, A Survey of Cell Biology, 212, pp.63-132. ⟨10.1016/S0074-7696(01)12004-8⟩. ⟨lirmm-00268610⟩
160 View
275 Download



Gmail Facebook X LinkedIn More