Mixture and Partition Models for Protein Evolution

Olivier Gascuel 1
1 MAB - Méthodes et Algorithmes pour la Bioinformatique
LIRMM - Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier
Abstract : Standard models of amino-acid replacement in proteins are based on Markovian rate matrices. I will review recent efforts to improve these models by (1) enhancing rate matrix estimation from large alignment databases, (2) combining several models (matrices) to account for solvent exposition and secondary structure, (3) designing site-specific models to describe biochemical constraints acting on amino-acid substitutions.
Type de document :
Communication dans un congrès
Statistical and Computational Challenges in Molecular Phylogenetics and Evolution, Apr 2008, Londres, United Kingdom. 2008, 〈http://royalsociety.org/event.asp?id=6067&month=9〉
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https://hal-lirmm.ccsd.cnrs.fr/lirmm-00324162
Contributeur : Olivier Gascuel <>
Soumis le : mercredi 24 septembre 2008 - 11:17:25
Dernière modification le : jeudi 24 mai 2018 - 15:59:22

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  • HAL Id : lirmm-00324162, version 1

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Olivier Gascuel. Mixture and Partition Models for Protein Evolution. Statistical and Computational Challenges in Molecular Phylogenetics and Evolution, Apr 2008, Londres, United Kingdom. 2008, 〈http://royalsociety.org/event.asp?id=6067&month=9〉. 〈lirmm-00324162〉

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