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Mixture and Partition Models for Protein Evolution

Olivier Gascuel 1
1 MAB - Méthodes et Algorithmes pour la Bioinformatique
LIRMM - Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier
Abstract : Standard models of amino-acid replacement in proteins are based on Markovian rate matrices. I will review recent efforts to improve these models by (1) enhancing rate matrix estimation from large alignment databases, (2) combining several models (matrices) to account for solvent exposition and secondary structure, (3) designing site-specific models to describe biochemical constraints acting on amino-acid substitutions.
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https://hal-lirmm.ccsd.cnrs.fr/lirmm-00324162
Contributor : Olivier Gascuel <>
Submitted on : Wednesday, September 24, 2008 - 11:17:25 AM
Last modification on : Thursday, May 24, 2018 - 3:59:22 PM

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  • HAL Id : lirmm-00324162, version 1

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Olivier Gascuel. Mixture and Partition Models for Protein Evolution. Statistical and Computational Challenges in Molecular Phylogenetics and Evolution, Apr 2008, Londres, United Kingdom. ⟨lirmm-00324162⟩

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