Post-stroke therapeutic game is considered as a promising rehabilitation tool since it can enhance the rehabilitation outcomes by creating a motivating environment. A therapeutic game could provide a personalized rehabilitation session in which the training intensity, duration and challenges can be adapted to patient's abilities and training needs. In this chapter, we present a generic adaptation approach that aims to customize the therapeutic game's experience. Our objective is to provide the readers with a design steering method that takes into account practical issues related to adaptation of post-stroke therapeutic games.