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Conference Papers Year : 2011

Modelling Protein Evolution


I'll describe our recent efforts to model protein evolution and amino-acid substitutions by (1) designing an easy to use pipeline to estimate amino-acid replacement matrices for specific protein groups, (2) using the protein structure, (3) simplifying mixture models that have been proposed so far. I'll discuss several issues related to models (e.g. complexity trade-off), biology (e.g. independence of nucleotide mutations) and theory (e.g. identifiability, prediction of ancestral sequences).
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lirmm-00715595 , version 1 (08-07-2012)


  • HAL Id : lirmm-00715595 , version 1


Olivier Gascuel. Modelling Protein Evolution. Phylogenetics: New data, New Phylogenetic Challenges, Isaac Newton Institute, Cambridge, United Kingdom. ⟨lirmm-00715595⟩
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