Modelling Protein Evolution

Olivier Gascuel 1, *
* Corresponding author
1 MAB - Méthodes et Algorithmes pour la Bioinformatique
LIRMM - Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier
Abstract : I'll describe our recent efforts to model protein evolution and amino-acid substitutions by (1) designing an easy to use pipeline to estimate amino-acid replacement matrices for specific protein groups, (2) using the protein structure, (3) simplifying mixture models that have been proposed so far. I'll discuss several issues related to models (e.g. complexity trade-off), biology (e.g. independence of nucleotide mutations) and theory (e.g. identifiability, prediction of ancestral sequences).
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https://hal-lirmm.ccsd.cnrs.fr/lirmm-00715595
Contributor : Olivier Gascuel <>
Submitted on : Sunday, July 8, 2012 - 6:52:20 PM
Last modification on : Thursday, May 24, 2018 - 3:59:22 PM

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  • HAL Id : lirmm-00715595, version 1

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Olivier Gascuel. Modelling Protein Evolution. Phylogenetics: New data, New Phylogenetic Challenges, Isaac Newton Institute, Cambridge, United Kingdom. ⟨lirmm-00715595⟩

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