Can Mammographic Assessments Lead to Consider Density as a Risk Factor for Breast Cancer? - LIRMM - Laboratoire d’Informatique, de Robotique et de Microélectronique de Montpellier Access content directly
Journal Articles European Journal of Radiology Year : 2013

Can Mammographic Assessments Lead to Consider Density as a Risk Factor for Breast Cancer?

Abstract

Admitting that mammographic breast density is an important independent risk factor for breast cancer in the general population, has a crucial economical health care impact, since it might lead to increasing screening frequency or reinforcing additional modalities. Thus, the impact of density as a risk factor has to be carefully investigated and might be debated. Some authors suggested that high density would be either a weak factor or confused with a masking effect. Others concluded that most of the studies have methodological biases in basic physics to quantify percentage of breast density, as well as in mammo- graphic acquisition parameters. The purpose of this review is to evaluate mammographic procedures and density assessments in published studies regarding density as a breast cancer risk. No standardiza- tion was found in breast density assessments and compared density categories. High density definitions varied widely from 25 to 75% of dense tissues on mammograms. Some studies showed an insufficient follow-up to reveal masking effect related to mammographic false negatives. Evaluating breast density impact needs thorough studies with consensual mammographic procedures, methods of density mea- surement, breast density classification as well as a standardized definition of high breast density. Digital mammography, more effective in dense breasts, should help to re-evaluate the issue of density as a risk factor for breast cancer.

Dates and versions

lirmm-00789705 , version 1 (18-02-2013)

Identifiers

Cite

Catherine Colin, Violaine Prince, Pierre-Jean Valette. Can Mammographic Assessments Lead to Consider Density as a Risk Factor for Breast Cancer?. European Journal of Radiology, 2013, 82, pp.404-411. ⟨10.1016/j.ejrad.2010.01.001⟩. ⟨lirmm-00789705⟩
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