The Influence of Rate Heterogeneity among Sites on the Time Dependence of Molecular Rates - LIRMM - Laboratoire d’Informatique, de Robotique et de Microélectronique de Montpellier Access content directly
Journal Articles Molecular Biology and Evolution Year : 2012

The Influence of Rate Heterogeneity among Sites on the Time Dependence of Molecular Rates

Abstract

Molecular evolutionary rate estimates have been shown to depend on the time period over which they are estimated. Factors such as demographic processes, calibration errors, purifying selection, and the heterogeneity of substitution rates among sites (RHAS) are known to affect the accuracy with which rates of evolution are estimated. We use mathematical modeling and Bayesian analyses of simulated sequence alignments to explore how mutational hotspots can lead to time-dependent rate estimates. Mathematical modeling shows that underestimation of molecular rates over increasing time scales is inevitable when RHAS is ignored. Although a gamma distribution is commonly used to model RHAS, we show that when the actual RHAS deviates from a gamma-like distribution, rates can either be under- or overestimated in a time-dependent manner. Simulations performed under different scenarios of RHAS confirm the mathematical modeling and demonstrate the impacts of time-dependent rates on estimates of divergence times. Most notably, erroneous rate estimates can have narrow credibility intervals, leading to false confidence in biased estimates of rates, and node ages. Surprisingly, large errors in estimates of overall molecular rate do not necessarily generate large errors in divergence time estimates. Finally, we illustrate the correlation between time-dependent rate patterns and differential saturation between quickly and slowly evolving sites. Our results suggest that data partitioning or simple nonparametric mixture models of RHAS significantly improve the accuracy with which node ages and substitution rates can be estimated.
Fichier principal
Vignette du fichier
mss140.pdf (570.97 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

lirmm-00805053 , version 1 (15-06-2021)

Licence

Attribution

Identifiers

Cite

Julien Soubrier, Mike Steel, Michael S.Y. Lee, Clio Der Sarkissian, Stéphane Guindon, et al.. The Influence of Rate Heterogeneity among Sites on the Time Dependence of Molecular Rates. Molecular Biology and Evolution, 2012, 29 (11), pp.3345-3358. ⟨10.1093/molbev/mss140⟩. ⟨lirmm-00805053⟩
101 View
82 Download

Altmetric

Share

Gmail Facebook X LinkedIn More