Three-dimensional (3D) integration is a fast emerging technology that offers integration of high density, fast performance and heterogeneous circuits in a small footprint. Through-Silicon-Vias (TSVs) enable 3D integration by providing fast performance and short interconnects among tiers. However, they are also susceptible to defects that occur during manufacturing steps and cause crucial reliability issues. In this paper, we perform an analysis of resistive-open defects (ROD) on TSVs considering coupling effects (i.e. inductive and capacitive) and a wide frequency spectrum. Our experiments show that both substrate coupling and switching frequency can have a significant impact on weak open TSV behavior.