NP Hard problems are not believed to be exactly solvable through general polynomial time algorithms. Hybrid quantum-classical algorithms to address such combinatorial problems have been of great interest in the past few years. Such algorithms are heuristic in nature and aim to obtain an approximate solution. Significant improvements in computational time and/or the ability to treat large problems are some of the principal promises of quantum computing in this regard. The hardware, however, is still in its infancy and the current Noisy Intermediate Scale Quantum (NISQ) computers are not able to optimize industrially relevant problems. Moreover, the storage of qubits and introduction of entanglement require extreme physical conditions. An issue with quantum optimization algorithms such as QAOA is that they scale linearly with problem size. In this paper, we build upon a proprietary methodology which scales logarithmically with problem size – opening an avenue for treating optimization problems of unprecedented scale on gate-based quantum computers. In order to test the performance of the algorithm, we first find a way to apply it to a handful of NP-hard problems: Maximum Cut, Minimum Partition, Maximum Clique, Maximum Weighted Independent Set. Subsequently, these algorithms are tested on a quantum simulator with graph sizes of over a hundred nodes and on a real quantum computer up to graph sizes of 256. To our knowledge, these constitute the largest realistic combinatorial optimization problems ever run on a NISQ device, overcoming previous problem sizes by almost tenfold.