Smooth Muscle Model for Functional Electrical Stimulation applications : Simulation of realistic bladder behavior under FES

Jeremy Laforet 1, * David Guiraud 1
* Auteur correspondant
1 DEMAR - Artificial movement and gait restoration
LIRMM - Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier, CRISAM - Inria Sophia Antipolis - Méditerranée
Abstract : We present here a major update of our smooth muscle model. It's aim is to enable the simulation of smooth muscle contraction under functional electrical stimulation (FES). The main addition is a model of calcium dynamics in the smooth muscle cell. It links the calcium concentration to the electrical potential of the membrane cell, therefore to the neural stimulation. This concentration is used to command the microscopic mechanics of the muscle, leading to contraction. We also refined the mechanical model. As smooth muscle have way slower dynamics than striated ones, it is possible to neglected the second order terms. We choose to simulate a well known example : the behavior of the bladder under the stimulation of a Finetech / Brindley implant. This way we can compare our qualitative results with the experimental data available in the literature. They show good consistency both in shape and time course. To obtain quantitative simulations, we need to perform the identification of the model through in-vivo testing on animals. Once this validation step done, it will be possible to apply our methodology to human bladder.
Type de document :
Communication dans un congrès
EMBC: Engineering in Medicine and Biology Conference, Aug 2008, Vancouver, BC, Canada. 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp.3702-3705, 2008, 〈10.1109/IEMBS.2008.4650013〉
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https://hal-lirmm.ccsd.cnrs.fr/lirmm-00346127
Contributeur : Isabelle Gouat <>
Soumis le : jeudi 11 décembre 2008 - 10:20:17
Dernière modification le : jeudi 24 mai 2018 - 15:59:23

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Jeremy Laforet, David Guiraud. Smooth Muscle Model for Functional Electrical Stimulation applications : Simulation of realistic bladder behavior under FES. EMBC: Engineering in Medicine and Biology Conference, Aug 2008, Vancouver, BC, Canada. 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp.3702-3705, 2008, 〈10.1109/IEMBS.2008.4650013〉. 〈lirmm-00346127〉

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