The ancient Yakuts: a population genetic enigma

Christine Keyser 1 Clemence Hollard 1 Angela Gonzalez 1 Jean-Luc Fausser 1 Eric Rivals 2, 3 Anatoly Nikolayevich Alexeev 4 Alexandre Riberon 5 Eric Crubezy 1 Bertrand Ludes 1, 6
1 AMIS - Anthropobiologie Moléculaire et Imagerie de Synthèse
2 MAB - Méthodes et Algorithmes pour la Bioinformatique
LIRMM - Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier
3 IBC - Institut de Biologie Computationnelle
4 Medical Institute [Yakutsk]
5 EDB - Evolution et Diversité Biologique
6 Institut de Médecine Légale - IML (Paris, France)
Abstract : This study is part of an ongoing project aiming at determining the ethnogenesis of an eastern Siberian ethnic group, the Yakuts, on the basis of archaeological excavations carried out over a period of 10 years in three regions of Yakutia: Central Yakutia, the Vilyuy River basin and the Verkhoyansk area. In this study, genetic analyses were carried out on skeletal remains from 130 individuals of unknown ancestry dated mainly from the fifteenth to the nineteenth century AD. Kinship studies were conducted using sets of commercially available autosomal and Y-chromosomal short tandem repeats (STRs) along with hypervariable region I sequences of the mitochondrial DNA. An unexpected and intriguing finding of this work was that the uniparental marker systems did not always corroborate results from autosomal DNA analyses; in some cases, false-positive relationships were observed. These discrepancies revealed that 15 autosomal STR loci are not sufficient to discriminate between first degree relatives and more distantly related individuals in our ancient Yakut sample. The Y-STR analyses led to similar conclusions, because the current Y-STR panels provided the limited resolution of the paternal lineages.
Keywords : Yakuts Short tandem repeats Ancient DNA Kinship
Type de document :
Article dans une revue
Philosophical Transactions of the Royal Society B: Biological Sciences, Royal Society, The, 2015, Discussion meeting issue ‘Ancient DNA: the first three decades’, 370 (1660), pp.20130385. 〈http://rstb.royalsocietypublishing.org/content/370/1660/20130385〉. 〈10.1098/rstb.2013.0385〉
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Contributeur : Eric Rivals <>
Soumis le : jeudi 2 juillet 2015 - 10:21:41
Dernière modification le : mercredi 10 octobre 2018 - 14:28:13
Document(s) archivé(s) le : mardi 25 avril 2017 - 22:05:12

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Christine Keyser, Clemence Hollard, Angela Gonzalez, Jean-Luc Fausser, Eric Rivals, et al.. The ancient Yakuts: a population genetic enigma. Philosophical Transactions of the Royal Society B: Biological Sciences, Royal Society, The, 2015, Discussion meeting issue ‘Ancient DNA: the first three decades’, 370 (1660), pp.20130385. 〈http://rstb.royalsocietypublishing.org/content/370/1660/20130385〉. 〈10.1098/rstb.2013.0385〉. 〈lirmm-01170676〉

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