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Journal Articles Science Advances Year : 2017

Population genomics of picophytoplankton unveils novel chromosome hypervariability

Romain Blanc-Mathieu
Marc Krasovec
  • Function : Author
Sheree Yau
  • Function : Author
Elodie Desgranges
  • Function : Author
Joel Martin
Wendy Schackwitz
  • Function : Author
Alan Kuo
Gerald Salin
Cecile Donnadieu
  • Function : Author
  • PersonId : 1204671
Sophie Sanchez-Ferandin
  • Function : Author
Hervé Moreau
  • Function : Author
Igor V Grigoriev
Nigel Grimsley
  • Function : Author
  • PersonId : 974062
Adam Eyre-Walker
  • Function : Author
Gwenael Piganeau

Abstract

Tiny photosynthetic microorganisms that form the picoplankton (between 0.3 and 3 mm in diameter) are at the base of the food web in many marine ecosystems, and their adaptability to environmental change hinges on standing genetic variation. Although the genomic and phenotypic diversity of the bacterial component of the oceans has been intensively studied, little is known about the genomic and phenotypic diversity within each of the diverse eukaryotic species present. We report the level of genomic diversity in a natural population of Ostreococcus tauri (Chlorophyta, Mamiellophyceae), the smallest photosynthetic eukaryote. Contrary to the expectations of clonal evolution or cryptic species, the spectrum of genomic polymorphism observed suggests a large panmictic population (an effective population size of 1.2 × 10 7) with pervasive evidence of sexual reproduction. De novo assemblies of low-coverage chromosomes reveal two large candidate mating-type loci with suppressed recom-bination, whose origin may pre-date the speciation events in the class Mamiellophyceae. This high genetic diversity is associated with large phenotypic differences between strains. Strikingly, resistance of isolates to large double-stranded DNA viruses, which abound in their natural environment, is positively correlated with the size of a single hypervariable chromosome, which contains 44 to 156 kb of strain-specific sequences. Our findings highlight the role of viruses in shaping genome diversity in marine picoeukaryotes.
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lirmm-01842137 , version 1 (17-07-2018)

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Attribution - NonCommercial

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Romain Blanc-Mathieu, Marc Krasovec, Maxime Hebrard, Sheree Yau, Elodie Desgranges, et al.. Population genomics of picophytoplankton unveils novel chromosome hypervariability. Science Advances , 2017, 3 (7), pp.e1700239. ⟨10.1126/sciadv.1700239⟩. ⟨lirmm-01842137⟩
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