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In vitro impedance spectroscopy: A MEA-based measurement bench for myoblasts cultures monitoring

Abstract : Bioimpedance spectroscopy is a promising tool for non-invasive monitoring of tissue structure and fluids. With the objective of using it to assess muscle fatigue in vitro, we have developed a measurement bench allowing the monitoring of myoblasts cultures by bioimpedance measurements. This work presents the setup and its characterization, combining modeling and measurements. This setup relies on a microelectrodes array and a commercial impedance analyzer. Its characterization with Phosphate Buffered Saline is coherent with our simulation. The impedance increases at low frequencies after several cell cultures, due to a degradation of the microelectrode interface. Nevertheless, the measurement bench allows us to detect the presence of myoblasts covering the electrodes in a frequency range from 10 kHz to 100 kHz. The measurement bench is therefore suitable to explore the relative impedance variation as a signature of muscle fatigue.
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https://hal-lirmm.ccsd.cnrs.fr/lirmm-03628267
Contributor : Serge Bernard Connect in order to contact the contributor
Submitted on : Friday, April 1, 2022 - 7:39:30 PM
Last modification on : Saturday, April 2, 2022 - 9:33:06 AM

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Alexia Bailleul, Julien Claudel, Florence Poulletier de Gannes, Gilles N’kaoua, Florian Kolbl, et al.. In vitro impedance spectroscopy: A MEA-based measurement bench for myoblasts cultures monitoring. DCIS 2021 - 36th Conference on Design of Circuits and Integrated Systems, Nov 2021, Vila do Conde, Portugal. pp.1-6, ⟨10.1109/DCIS53048.2021.9666172⟩. ⟨lirmm-03628267⟩

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