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Multiscale modeling of skeletal muscle properties and experimental validations in isometric conditions

Hassan El Makssoud 1, 2 David Guiraud 1, 2, * Philippe Poignet 2 Mitsuhiro Hayashibe 2 Pierre-Brice Wieber 3, 4 Ken Yoshida 5, 6 Christine Azevedo Coste 2
* Corresponding author
2 DEMAR - Artificial movement and gait restoration
LIRMM - Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier, CRISAM - Inria Sophia Antipolis - Méditerranée
4 BIPOP - Modelling, Simulation, Control and Optimization of Non-Smooth Dynamical Systems
Grenoble INP - Institut polytechnique de Grenoble - Grenoble Institute of Technology, LJK - Laboratoire Jean Kuntzmann, Inria Grenoble - Rhône-Alpes
Abstract : In this article, we describe an approach to model the electromechanical behavior of the skeletal muscle based on the Huxley formulation. We propose a model that complies with a well established macroscopic behavior of striated muscles where force-length, force-velocity, and Mirsky-Parmley properties are taken into account. These properties are introduced at themicroscopic scale and related to a tentative explanation of the phenomena. The method used integrates behavior ranging from the microscopic to the macroscopic scale, and allows the computation of the dynamics of the output force and stiffness controlled byEMG or stimulation parameters. The model can thus be used to simulate and carry out research to develop control strategies using electrical stimulation in the context of rehabilitation. Finally, through animal experiments, we estimated model parameters using a Sigma Point Kalman Filtering technique and dedicated experimental protocols in isometric conditions and demonstrated that the model can accurately simulate individual variations and thus take into account subject dependent behavior
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Submitted on : Wednesday, October 12, 2011 - 3:52:00 PM
Last modification on : Thursday, March 18, 2021 - 7:22:01 PM

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Hassan El Makssoud, David Guiraud, Philippe Poignet, Mitsuhiro Hayashibe, Pierre-Brice Wieber, et al.. Multiscale modeling of skeletal muscle properties and experimental validations in isometric conditions. Biological Cybernetics (Modeling), Springer Verlag, 2011, 105, pp.121-138. ⟨10.1007/s00422-011-0445-7⟩. ⟨lirmm-00631528⟩



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