Stimulation of small diameter myelinated and unmyelinated abdominal vagal neurons using high frequency pulses

Charles-Henri Malbert 1 Jean Louis Divoux 2 Paweł Maciejasz 2, 3 Chloé Picq 2 David Andreu 3 David Guiraud 3
1 PRISM - Plate-forme Rennaise d'Imagerie et Spectroscopie Structurale et Métabolique
2 AXONIC - OBELIA dept
3 DEMAR - Artificial movement and gait restoration
CRISAM - Inria Sophia Antipolis - Méditerranée , LIRMM - Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier
Abstract : The voltage required to stimulate small diameter myelinated (Adelta fibres) and unmyelinated (C fibres) neurons consistently is so large that it is unsafe for chronic vagal stimulation. We present here a solution that reduces by 80% the amount of electrical charge necessary to produce action potential. These solutions were tested in a porcine model that allowed simultaneously to locate the origin of the afferent neurons, to stimulate the vagal trunks at distance from the recording electrode and to record the evoked activity of one neuron using the single afferent method. The reduction in current supplied by the most effective pulse pattern makes possible to incorporate this solution in an implanted device without damaging the vagal nerve
Keywords : unmyelinated abdominal vagal neuron stimulation vagal trunks Animals Electric potential Electrodes Neurons Shape Software Adelta fibres bioelectric potentials biomedical electrodes neurophysiology small diameter myelinated abdominal vagal neuron stimulation pulse pattern recording electrode single afferent method porcine model implanted device high frequency pulses evoked activity electrical charge Stomach C fibres chronic vagal stimulation action potential
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Conference papers
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https://hal-lirmm.ccsd.cnrs.fr/lirmm-01586137
Contributor : David Guiraud <>
Submitted on : Tuesday, September 12, 2017 - 2:56:01 PM
Last modification on : Monday, September 2, 2019 - 2:46:17 PM

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LIRMM | IRSTEA | INRA | TDS-MACS | UNIV-RENNES1 | BIOSIT | DEMAR | MIPS | INRIA | UNIV-MONTPELLIER | UNIV-RENNES | CAMIN

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Charles-Henri Malbert, Jean Louis Divoux, Paweł Maciejasz, Chloé Picq, David Andreu, et al.. Stimulation of small diameter myelinated and unmyelinated abdominal vagal neurons using high frequency pulses. NER: Neural Engineering, Apr 2015, Montpellier, France. pp.510-513, ⟨10.1109/NER.2015.7146671⟩. ⟨lirmm-01586137⟩

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