Stimulation of small diameter myelinated and unmyelinated abdominal vagal neurons using high frequency pulses

Charles-Henri Malbert 1 Jean Louis Divoux 2 Paweł Maciejasz 2, 3 Chloé Picq 2 David Andreu 3 David Guiraud 3
1 PRISM - Plate-forme Rennaise d'Imagerie et Spectroscopie Structurale et Métabolique
2 AXONIC - OBELIA dept
3 DEMAR - Artificial movement and gait restoration
CRISAM - Inria Sophia Antipolis - Méditerranée , LIRMM - Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier
Abstract : The voltage required to stimulate small diameter myelinated (Adelta fibres) and unmyelinated (C fibres) neurons consistently is so large that it is unsafe for chronic vagal stimulation. We present here a solution that reduces by 80% the amount of electrical charge necessary to produce action potential. These solutions were tested in a porcine model that allowed simultaneously to locate the origin of the afferent neurons, to stimulate the vagal trunks at distance from the recording electrode and to record the evoked activity of one neuron using the single afferent method. The reduction in current supplied by the most effective pulse pattern makes possible to incorporate this solution in an implanted device without damaging the vagal nerve
Keywords : action potential chronic vagal stimulation Stomach C fibres electrical charge evoked activity high frequency pulses implanted device porcine model pulse pattern recording electrode single afferent method small diameter myelinated abdominal vagal neuron stimulation unmyelinated abdominal vagal neuron stimulation vagal trunks Animals Electric potential Electrodes Neurons Shape Software Adelta fibres bioelectric potentials biomedical electrodes neurophysiology
Type de document :
Communication dans un congrès
IEEE Neural Engineering Conference, Apr 2015, Montpellier, France. IEEE, pp.510-513, 2015, 〈https://neuro.embs.org/2015/〉. 〈10.1109/NER.2015.7146671〉
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https://hal-lirmm.ccsd.cnrs.fr/lirmm-01586137
Contributeur : David Guiraud <>
Soumis le : mardi 12 septembre 2017 - 14:56:01
Dernière modification le : mardi 22 janvier 2019 - 15:24:02

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Charles-Henri Malbert, Jean Louis Divoux, Paweł Maciejasz, Chloé Picq, David Andreu, et al.. Stimulation of small diameter myelinated and unmyelinated abdominal vagal neurons using high frequency pulses. IEEE Neural Engineering Conference, Apr 2015, Montpellier, France. IEEE, pp.510-513, 2015, 〈https://neuro.embs.org/2015/〉. 〈10.1109/NER.2015.7146671〉. 〈lirmm-01586137〉

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