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Journal Articles Clinical Neurophysiology Year : 2018

Phantom somatosensory evoked potentials following selective intraneural electrical stimulation in two amputees

Jean-Louis Divoux
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Loïc Wauters
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Abstract

Objective The aim of the paper is to objectively demonstrate that amputees implanted with intraneural interfaces are truly able to feel a sensation in the phantom hand by recording “phantom” somatosensory evoked potentials from the corresponding brain areas. Methods We implanted four transverse intrafascicular multichannel electrodes, available with percutaneous connections to a multichannel electrical stimulator, in the median and ulnar nerves of two left trans-radial amputees. Two channels of the implants that were able to elicit sensations during intraneural nerve stimulation were chosen, in both patients, for recording somatosensory evoked potentials. Results We recorded reproducible evoked responses by stimulating the median and the ulnar nerves in both cases. Latencies were in accordance with the arrival of somatosensory information to the primary somatosensory cortex. Conclusion Our results provide evidence that sensations generated by intraneural stimulation are truly perceived by amputees and located in the phantom hand. Moreover, our results strongly suggest that sensations perceived in different parts of the phantom hand result in different evoked responses. Significance Somatosensory evoked potentials obtained by selective intraneural electrical stimulation in amputee patients are a useful tool to provide an objective demonstration of somatosensory feedback in new generation bidirectional prostheses.
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lirmm-01767540 , version 1 (16-04-2018)

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Giuseppe Granata, Riccardo Di Iorio, Roberto Romanello, Francesco Iodice, Stanisa Raspopovic, et al.. Phantom somatosensory evoked potentials following selective intraneural electrical stimulation in two amputees. Clinical Neurophysiology, 2018, 129 (6), pp.1117-1120. ⟨10.1016/j.clinph.2018.02.138⟩. ⟨lirmm-01767540⟩
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