On the hardness of approximating Linearization of Scaffolds sharing Repeated Contigs
Abstract
Solutions to genome scaffolding problems can be represented as paths and cycles in a "solution graph". However, when working with repetitions, such solution graph may contain branchings and they may not be uniquely convertible into sequences. Having introduced, in a previous work, various ways of extracting the unique parts of such solutions, we extend previously known NP-hardness results to the case that the solution graph is planar, bipartite, and subcubic, and show the APX-completeness in this case. We also provide some practical tests.
Domains
Bioinformatics [q-bio.QM]
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recomb-cg_2018_on_the_hardness_of_approximating_linearization_of_scaffolds_sharing_repeated_contigs.pdf (542.91 Ko)
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